Conflicting results in patients with gliomas have been reported for other glutamate-related signaling pathways, such as solute carrier family, xCT, BCAT1, PI3K mutation, BRAF mutation, GLT-1, alpha-thalassemia mental retardation X-linked retention, 1p/19q co-deletion, p53 expression, and glutamate receptor genes. Here, TP53 is linked to central nervous system cancer.