MYC and neoplasm: The strong correlation between MYC targets, ESURATAG expression, EMT markers and aging signature (Figure 7E) further suggests that MYC-driven ER stress adaptation not only supports proliferation and progression, but may also promote tumor aggressiveness in an-aging dependent manner as MYC is being actively recognized as a crucial factor in driving aging-related cancer onset and progression (Hofmann et al., 2015;Wang et al., 2023).