Loss of NRF2 in mice (NRF2−/−) exacerbates the progression of IS-related brain injury, with NRF2-deficient mice exhibiting more severe cerebral infarctions on day 3 and poorer sensorimotor function on day 28 in a permanent ischemic model (Jerotic et al., 2019). The gene discussed is NFE2L2; the disease is cerebral infarction.