IDH1 and astrocytoma (excluding glioblastoma): Additionally, we acknowledge the limitation that the current work focused on adult diffuse gliomas (ie, astrocytoma, IDH-mutant; oligodendroglioma, IDH-mutant, 1p/19q-codeleted; glioblastoma, IDH-wildtype—as defined by Louis et al.3) does not address the clinical applicability of the model in distinguishing other typical IDHwt tumors with similar histological features, such as pilocytic astrocytoma.