Additionally, we acknowledge the limitation that the current work focused on adult diffuse gliomas (ie, astrocytoma, IDH-mutant; oligodendroglioma, IDH-mutant, 1p/19q-codeleted; glioblastoma, IDH-wildtype—as defined by Louis et al.3) does not address the clinical applicability of the model in distinguishing other typical IDHwt tumors with similar histological features, such as pilocytic astrocytoma. This evidence concerns the gene IDH2 and astrocytoma (excluding glioblastoma).