Additionally, we acknowledge the limitation that the current work focused on adult diffuse gliomas (ie, astrocytoma, IDH-mutant; oligodendroglioma, IDH-mutant, 1p/19q-codeleted; glioblastoma, IDH-wildtype—as defined by Louis et al.3) does not address the clinical applicability of the model in distinguishing other typical IDHwt tumors with similar histological features, such as pilocytic astrocytoma. The gene discussed is IDH2; the disease is glioblastoma.