EZH2 has been shown to promote tumor angiogenesis,46 while in other models, such as limb ischemia, opposite activity was described as well.47 The common ground in these was vascular normalization induced by EZH2 inhibition which has been shown to be able to inhibit tumor growth48 and might have also been an important mechanism in our model. This evidence concerns the gene EZH2 and limb ischemia.