EZH2 and meningioma: Analyses in the validation cohort showed that EZH2 H-score is significantly higher in CNS WHO grade 2 meningiomas showing elevated (4–19/10 HPF) mitotic index compared to CNS WHO grade 1 tumors (P < .01), which is not true in CNS WHO grade 2 meningiomas with brain invasion, but without elevated mitotic activity (Supplementary Figure S2A and B).