CDKN2A and melanoma: A possible player in this process is microRNA miR-31 encoded in the 9p21.3 region, which is frequently co-deleted with CDKN2A in melanoma, and inhibits EZH2 expression.32 To the best of our knowledge, the presented data are the first showing higher EZH2 expression in the context of H3 K27me3 loss.