In colorectal cancer (CRC), the iNKT-neutrophil axis paradoxically suppresses anti-tumor immunity, with tumor-infiltrating iNKT exhibiting a pro-tumorigenic phenotype characterized by GM-CSF and IL-17 secretion and expression of exhaustion markers (PD-1, TIGIT, TIM-3) (141). Here, HAVCR2 is linked to neoplasm.