SELL and neoplasm: The therapeutic relevance of these subsets was demonstrated in a xenograft model of Epstein-Barr virus-driven B-lymphoma, where CD4+ iNKT cells functioned in an adjuvant-like manner to enhance anti-tumor responses by antigen-specific T cells (134), while CD62L expression further distinguished memory-like iNKT, correlating with enhanced persistence, proliferation, and antitumor activity (135, 136).