Conversely, pathways such as DNA replication, homologous recombination, cell cycle, Fanconi anemia, progesterone-mediated oocyte maturation, p53 signaling, oocyte meiosis, focal adhesion, cellular senescence, pathways in cancer, efferocytosis, ECM-receptor interaction, small cell lung cancer, motor proteins, PI3K-Akt signaling, Rap1 signaling, and MAPK signaling exhibited with downregulated DEGs across all vaccine groups (Supplementary Figures S4, S5). Here, AKT1 is linked to cancer.