TNF and rheumatoid arthritis: At the 24 h time point, only a few pathways such as rheumatoid arthritis, viral protein interaction with cytokine and cytokine receptor, IL-17 signaling pathway, hematopoietic cell lineage, TNF signaling pathway, NF-kappa B signaling pathway, and cytokine-cytokine receptor interaction were uniquely enriched in upregulated DEGs in SKO, DKO, and TKO-D; almost no pathways matched with BCG for the TKO-Z and QKO groups.