In PPARα-deficient murine colon cancer models, increased levels of DNMT1 and PRMT6 promote colon carcinogenesis by mediating methylation of p21 and p27, respectively; the PPAR agonist fenofibrate suppresses AOM/DSS-induced colorectal carcinogenesis (94). The gene discussed is PPARA; the disease is malignant colon neoplasm.