CXCL8 and type 1 diabetes mellitus: The CXCL8-CXCR1/2 axis plays a crucial role in T1D onset and progression, acting through immune (e.g., neutrophils) and non-immune (e.g., β cells, adipocytes) pathways, such that CXCR1/2-targeting therapies represent a multifaceted treatment approach.