CXCR1 and type 1 diabetes mellitus: Here, we describe the crucial roles of the CXCL8-CXCR1/2 axis in T1D onset and progression, with contributions of the axis through immune cells, such as neutrophils and T cells, but also through non-immune cells, such as β cells, adipocytes and podocytes, highlighting its potential as a wide-reaching therapeutic target.