To examine the role of the nitric oxide (NO) pathway in the effects of MPFF on VCR-induced peripheral neuropathy (VIPN), we also tested the effect of L-arginine (100 mg/kg i.p.)as a NO precursor and L-NAME (20 mg/kg i.p.)as a nitric oxide synthase (NOS) inhibitor. The gene discussed is NOS1; the disease is peripheral neuropathy.