O6-methylguanine DNA methyltransferase (MGMT) methylation is well known to affect glioblastoma behavior and response to therapy and may have implications in PitNETs, as well.34 Approximately 40% of both functional and nonfunctional PitNETs exhibit MGMT methylation, which is associated with a lower rate of tumor regrowth.1,34. Here, MGMT is linked to neoplasm.