RASSF1 and neoplasm: The Ras-association domain family 1 (RASSF1A) gene is a tumor suppressor with hypermethylation seen frequently in malignant breast, lung, genitourinary, gastrointestinal, and sinonasal cancers.33 Promoter region methylation of RASSF1A has variable frequency among PITNET subtypes and is most common in somatotroph, lactotroph, and corticotroph tumors.33 It can be detected in both aggressive and non-aggressive tumors; however, there is a slight correlation between Ki-67 and methylation status.7,33