CDH1 and neoplasm: Both E-cadherin (CDH1) and H-cadherin (CDH13) encode proteins that play a critical role in cell–cell adhesion.32 Downregulation via promoter hypermethylation is tumor-specific and found in all tumor subtypes.32 Methylation is associated with invasive behavior in PitNETs and may play a role in predicting tumor aggressiveness.32