POMC and neoplasm: Pituitary RT has been used both prophylactically to prevent the development of Nelson’s syndrome and as a secondary treatment option to control tumor progression and ACTH secretion.53 In the former case, in a retrospective series of 43 patients treated with BA and prophylactic SRS (33 with SRS before BA and 10 without), RT significantly reduced the risk of Nelson’s syndrome development.54 However, due to the conflicting reports regarding its benefits, routine prophylactic pituitary irradiation is not recommended.53