It reduces oxidative stress markers such as NF-κB, ROS (O2−, OH), and aldose reductase (AR) and increases antioxidant enzyme activities such as Superoxide Dismutase (SOD), Glutathione (GSH) and Catalase (CAT) which protect against diabetic related complications such as diabetic nephropathy, neuropathy, and vascular complications (88). The gene discussed is CAT; the disease is neuropathy.