Patients (men and women, excluding pregnant women) with laboratory parameters such as significantly deranged CRP values and suspected perforation are advised to go for CT with intravenous contrast agents to rule out appendicitis-associated pathologies [30]. Due to the high specificity and relatively low sensitivity of US, we corroborate its efficacy in diagnosing appendicitis across varied presentations (appendicitis, acute appendicitis, appendicitis with the absence or presence of secondary signs, and appendicitis with or without comorbidities). This evidence concerns the gene CRP and appendicitis.