He also had multiple lymph node enlargements, severe peripheral nerve damage, nephrotic syndrome with abnormal renal function, severe heart failure, HES, moderate anemia, patchy lung shadows, pancreatic enlargement, significantly elevated IgG4 and IgE levels, slightly elevated rheumatoid factor (RF), low titer positive P-anti-neutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase-ANCA (MPO-ANCA), severe eosinophilic infiltration in the kidney, and IgG4-related interstitial nephritis. The gene discussed is IGHE; the disease is hypereosinophilic syndrome.