Alb/LF NPs encapsulating DDC/Cu-Fe facilitate brain accumulation, where DDC/Cu-Fe cooperatively induces glioma cell ferroptosis through oxidative stress, activates T cell immunity, and suppresses TAMs by FROUNT (also known as NUP85) inhibition (Table 1) (Wang R. et al., 2024). Here, NUP85 is linked to central nervous system cancer.