As inflammation is a critical pathogenic mechanism and physiological manifestation of preeclampsia, we assessed the activation of the NF-κB pathway by analyzing the mRNA levels of key inflammatory factors, including IL-6, IL-1β, TNF-α, NF-κB-p50, and NF-κB-Rel A. The results demonstrate that SA can significantly modulate the expression levels of these inflammatory factors in the placental tissues of preeclampsia mice (Figure 2i). Here, NFKB1 is linked to preeclampsia.