The observed outcomes in this study corroborate earlier findings that Tan IIA exhibits neuroprotective effects in AD treatment (Subedi and Gaire, 2021; Sherawat and Mehan, 2023), primarily through modulation of inflammation, oxidative stress, apoptosis, synaptic plasticity, Aβ aggregation, and Tau hyperphosphorylation (Figure 11). The gene discussed is MAPT; the disease is Alzheimer disease.