APP and neurodegenerative disease: KD provides the brain with ketone bodies as an alternative fuel for glucose, enhances the genesis of new mitochondria, increases adenosine triphosphate production, produces fewer reactive oxygen species than glucose, decreases mitochondrial interaction of amyloid precursor protein, modifies gene expression associated with neurodegenerative diseases, and improves gene expression associated with metabolism in the hippocampus (Taylor et al., 2022).