The aim of this study was to investigate the concentration of proinflammatory cytokines (IL-1β, IL-6, and TNFα) in plasma, homogenates of the brain and spinal cord, serum circulating immune complexes (CICs), the apoptosis marker APO-1/Fas, and the content of glycosphingolipids during experimental autoimmune encephalomyelitis (EAE) and its treatment. The gene discussed is IL1B; the disease is experimental autoimmune encephalomyelitis.