Although researchers found similarities between the two diseases based on gene ontology (GO) and protein-protein interactions (PPIs), for instance, the hub gene SLC2A2 (which encodes the transmembrane carrier protein GLUT2) connects the most DEGs in both AD and T2DM [61],[62], no definitive evidence has yet established a causal link. This evidence concerns the gene SLC2A2 and type 2 diabetes mellitus.