The pathology in AD is characterized by the extracellular deposition of amyloid plaques of amyloid-β (Aβ) peptides (senile plaques, SPs) that originated from the proteolysis of APP between neurons in the brain and intracellular aggregates of neurofibrillary tangles (NFTs) of hyperphosphorylated tau proteins inside the neurons. This evidence concerns the gene APP and Alzheimer disease.