APP and obesity due to melanocortin 4 receptor deficiency: In a way, these findings [25],[26] were the first demonstration of how such epigenetic defects (potentially reversible) could provide a target for therapeutic interventions through the AS process of APP gene observed from LND, while the impacts of APP on different human diseases such as neurodevelopmental and neurodegenerative disorders, metabolic disorders, diabetes, obesity, and cancer have been reported in the literature.