DUX4 and facioscapulohumeral muscular dystrophy: In another study, U7-small nuclear RNA (snRNA) antisense expression cassettes (U7-asDUX4) were developed to inhibit DUX4 expression in FSHD, offering a potential gene therapy approach that may require only a single administration and could be combined with other therapies to enhance DUX4 silencing [58].