PLA2G6 and neurodegeneration with brain iron accumulation 2A: The progressive neurobiological alterations that characterize INAD, mainly at the central nervous system level, as a consequence of the enzymatic dysfunction of iPLA2-VIA encoded by the PLA2G6 gene, reflect the disruption of multiple important cellular processes that converge in axonal degeneration, synaptic disruption, and neuronal loss, key elements that explain the progressive and multisystemic symptomatology observed in patients.