Specifically, lactate released from CAFs facilitated the H3K18 lactylation of METTL3, which led to ZNF384 upregulation through METTL3‐mediated m6A modification, and ZNF384 subsequently activated POLR3G transcription, ultimately increasing the EMT process of NSCLC cells. The gene discussed is POLR3G; the disease is non-small cell lung carcinoma.