METTL3 and non-small cell lung carcinoma: Drawing from the aforementioned research and bioinformatics data analysis, we supposed that lactate released by CAFs increased METTL3 expression via H3K18 lactylation, and upregulation of METTL3 promoted the m6A modification of ZNF384 to activate POLR3G transcription, thereby facilitating cells migration and EMT in NSCLC.