This heterogeneity is first reflected in tissue distribution and isoform specificity: FABP1 is primarily expressed in hepatocytes and promotes fatty acid oxidation in TAMs in HCC through the PPARG/CD36 axis[18]; FABP7, as a brain-type FABP, drives the migration and radioresistance of glioblastoma stem cells in glioblastoma (GBM) through the RXRα signaling pathway[23], while in breast cancer brain metastasis, it mediates a glycolytic phenotype to adapt to the brain microenvironment[141]. Here, RXRA is linked to breast cancer.