IGF1 and colorectal carcinoma: In terms of signaling pathways, FABPs can act through multiple pathways such as PPARγ, NF-κB, HIF-1α, and Wnt/β-catenin: FABP4 promotes lipid droplet formation in adipocytes through PPARγ[19], FABP5 induces EMT and lymphangiogenesis in cervical cancer through NF-κB[102], and FABP6 promotes CRC cell proliferation through the IGF signaling pathway[129].