The ESC HFA also suggested adjustment for obesity classes I, II and III by lowering the NT‐proBNP threshold by 25%, 30% and 40% in patients with BMI 30–34.9 kg/m2, 35–39.9 kg/m2 and ≥40 kg/m2, respectively. The gene discussed is NPPB; the disease is obesity due to melanocortin 4 receptor deficiency.