The American College of Cardiology/American Heart Association/Heart Failure Society of America (ACC/AHA/HFSA)6 and European Society of Cardiology (ESC)7 HF guidelines currently recommend a single NT‐proBNP cut‐off below 125 pg/mL to rule out chronic HF in the community7; however, patient factors including age, sex and body mass index (BMI), as well as comorbidities and therapies, can influence the level found on testing.11 This evidence concerns the gene NPPB and heart failure.