NT‐proBNP test performance at ESC HFA age‐adjusted rule‐in thresholds (≥125 pg/mL, ≥250 pg/mL and ≥500 pg/mL for <50 years, 50–74 years and ≥75 years, respectively) and a high‐risk threshold (≥2000 pg/mL) was assessed overall, by sex and body mass index (BMI) with ESC's suggested threshold reductions for obesity. Here, NPPB is linked to obesity due to melanocortin 4 receptor deficiency.