Substantial evidence suggests that the retromer complex plays a prominent role in PD pathogenesis, as mutations in VPS35, a core component of the complex, cause familial forms of PD (Vilariño‐Güell et al. 2011) and α‐Syn degradation is retromer‐dependent (Miura et al. 2014). The gene discussed is VPS35; the disease is Parkinson disease.