Consistent with these findings, our study demonstrated the upregulation of the Tlr4/NF‐κB pathway during cisplatin‐induced AKI, with elevated levels of inflammation‐associated cytokines and chemokines, such as IL‐1β, IL‐6, CXCL1, CXCL2 and CCL2 in kidneys, suggesting the central importance of the Tlr4/NF‐κB pathway in cisplatin‐induced AKI. Here, CXCL2 is linked to acute kidney injury.