Using a mouse model of AKI, we demonstrated that cisplatin‐induced obvious inflammation in the kidney, evidenced by increased macrophage and neutrophil infiltration, elevated expression of pro‐inflammatory cytokines, including interleukin‐1 beta (IL‐1β), IL‐6, C‐X‐C motif chemokine ligand (CXCL) 1, 2, 5, 20, and C‐C motif chemokine ligand (CCL) 2, and activation of the toll‐like receptor 4 (Tlr4)/nuclear factor‐kappa B (NF‐κB) pathway. This evidence concerns the gene IL6 and acute kidney injury.