TBX3 and cancer: Indeed, we demonstrate that in PDAC cells, PO inhibited TBX2 and TBX3 levels and exhibited potent cytotoxicity in 2D cell culture and 3D spheroids as well as PDAC patient‐derived organoids and recapitulated the anti‐cancer activities observed when TBX2 and TBX3 were depleted in 2D and 3D PDAC cell culture models.