Many studies have found that the key rate‐limiting enzymes of glycolysis, pyruvate kinase M2 (PKM2) and lactate dehydrogenase (LDH), during the course of HCC development, the expression of LDH A (LDHA), glucose transporters (GLUTs), hexokinase 2 (HK2), and pyruvate dehydrogenase kinase (PDK) were up‐regulated. This evidence concerns the gene HK2 and hepatocellular carcinoma.