The analysis displayed in the GEO database indicated that the expressions of the Warburg effect key enzyme PKM2, CSC reprogramming factors OCT4 and KLF4 and cancer stemness marker CD44 in HBV(+) HCC were higher than those of HBV(−) HCC, with statistical significance, p < 0.05 (Figure 1A). This evidence concerns the gene KLF4 and cancer.