These diseases, namely, cancer-associated retinopathy (CAR), are caused by lung cancer cells, particularly SCLC, cells expressing retina specific antigen, recoverin, being released into circulation, eliciting a high-affinity anti-recoverin autoantibody into the blood stream as a response, compromising the BRB (Bazhin et al. 2007) It has been evidenced that 15% of SCLC patient have both detectable recoverin autoantibodies in serum, prior to the clinical signs of CAR (Bazhin et al. 2007). The gene discussed is RCVRN; the disease is cancer-associated retinopathy.