FGF19 and SHP were observed to inhibit SREBF2 (sterol regulatory element binding transcription factor 2), which led to a reduction in intestinal NPC1L1 expression, cholesterol absorption and hypercholesterolemia.298 Another member of the nuclear receptor family, NR1A1, was reported to influence hepatic autophagy, lipid metabolism and adipocyte homeostasis by interacting with MED1 through a bridge formed by PGC1α.299,300. Here, SREBF2 is linked to familial hypercholesterolemia.