According to Byun and colleagues, hepatic FXR phosphorylation by FGF15/19-induced Src preserves cholesterol homeostasis and protects against atherosclerosis.307 PXR activation upregulated intermediates in the Kandutsch–Russell cholesterol synthesis pathway in the liver and induced a number of cholesterol synthesis genes, including the rate-limiting HMRCR. The gene discussed is NR1H4; the disease is atherosclerosis.