The targeting of NRs for the treatment of cardiovascular diseases has gained significant attention because of the pivotal role these receptors play in regulating the expression of genes involved in metabolic, inflammatory and lipid processes.361,396–398 Nuclear receptors, such as PPARs, LXR and FXR, are key regulators of lipid metabolism, glucose homeostasis and inflammation, all of which are critical factors in the development of cardiovascular diseases. This evidence concerns the gene NR1H4 and cardiovascular disorder.