PPARA and Hypoglycemia: However, fasting resulted in mild hypoglycemia and hypothermia in PPARαhep−/− mice, suggesting a role of PPARα activity in nonhepatic tissues.293 Liver-specific inactivation of Vps15, the essential regulatory subunit of class 3 PI3K, elicited mitochondrial depletion and failure to oxidize fatty acids through blunting of the transcriptional activity of PPARα.