NR4A1 and Parkinson disease: An additional interaction between the N-terminal intrinsically disordered region (IDR) of Nur77 and the N-terminal PB1 domain of p62/SQSTM1 allows tethering of clustered mitochondria to the autophagy machinery, which endows Nur77-p62/SQSTM1 condensates with the magnitude and liquidity to act on the mitochondria.319 In response to the pathological accumulation of α-synuclein (α-syn) fibrils in Parkinson’s disease (PD), Nur77 is translocated from the cytoplasm to the mitochondria to improve PHB-mediated mitophagy by regulating c-Abl phosphorylation.