NR3C1 and mood disorder: Dexamethasone reduces edema, prevents cerebrovascular leakage, and upregulates tight junction proteins at the BBB.420,421 Methylprednisolone improves memory and long-term potentiation at low doses but has dose-dependent effects, with high doses alleviating motor deficits in MS models but not cognition.422,423 GR antagonists, such as mifepristone and relacorilant, have shown efficacy in treating mood disorders, neurodegenerative conditions, and PTSD.