NR1D1 and central nervous system cancer: Suppressing TLX significantly reduced the in vivo growth of glioma allografts and xenografts, preserved the antitumor immune response and markedly decreased the number of PD-L1-positive cells and glioma-associated macrophages.330 Nuclear receptor subfamily 1 group D member 1 (NR1D1) acts as a transcriptional repressor and plays a key role in regulating inflammation.