For example, the activation of PPARγ by a polyphenolic compound, sinapic acid, was shown to ameliorate metabolic dysfunction and attenuate PCOS phenotypes in rats.458 Another study focusing on the downstream mechanism underlying PPAR-mediated alleviation of PCOS indicated that PPARα can bind to the promoter of FADS2, a ferroptosis-related gene, thus increasing FADS2 transcription. The gene discussed is PPARA; the disease is polycystic ovary syndrome.