ESRRB and metabolic dysfunction-associated steatohepatitis: In myeloid-specific RORα-deficient animals, Kupffer cells (KCs) and bone marrow-derived macrophages fail to undergo M2 polarization, rendering them more susceptible to high-fat-diet-induced nonalcoholic steatohepatitis (NASH).329 Additionally, the orphan nuclear receptor TLX directly bound to the CD274 (PD-L1) gene promoter, showing a strong positive correlation with PD-L1 overexpression.