GR abnormalities also underlie mood disorders such as depression and anxiety, as dysfunction in GR and MR signaling leads to maladaptive stress responses, dendritic retraction, and impaired serotonin activity.418,419 GR dysregulation in the prefrontal cortex and hippocampus has been linked to anxiety and depression-like behaviors in animal models. The gene discussed is NR3C2; the disease is depressive disorder.