In fact, all three PPAR family members, including PPARα, PPARβ/δ and PPARγ, play critical roles in PCOS via multiple mechanisms, such as the regulation of lipogenesis; glucose homeostasis; and fatty acid oxidation, synthesis and storage.457 Given the important function of PPARs in PCOS pathogenesis, modulating the activity of PPARs profoundly affects the development of PCOS. The gene discussed is PPARG; the disease is polycystic ovary syndrome.