PPARA and Other metabolic disease: For example, the overexpression of ER in breast cancer drives tumor growth,234 whereas aberrant AR can cause therapy resistance in prostate cancer.235 Impaired PPAR function is associated with metabolic disorders such as obesity and type 2 diabetes,236 whereas dysregulated liver X receptors (LXRs) disrupt cholesterol homeostasis, exacerbating cardiovascular disease.237 Aberrant GR activity exacerbates inflammatory conditions and may induce corticosteroid resistance.