Furthermore, FXR agonists such as GW4064 have demonstrated potential in alleviating inflammation and preserving intestinal barrier function in experimental colitis, primarily through the modulation of NF-κB signaling.432,433 In addition, GW4064 has been reported to downregulate scavenger receptors via FXR and indirectly inhibits HCV entry into cells.434. The gene discussed is NR1H4; the disease is colitis.