A conformational shift in Bcl2 and an increase in proapoptotic Bcl-xS protein levels are involved in Nur77-mediated kidney damage.258 Furthermore, YAP controls the transcription, phosphorylation and mitochondrial localization of NR4A1 to mediate the proapoptotic and antitumor actions of the Hippo pathway. This evidence concerns the gene NR4A1 and Nephropathy.