Among the LMRGs associated with differentially methylated promoter CpG sites between Cs+ and Cs− HCC tumors, six LMRGs associated with differentially methylated promoter CpG sites were identified: OBSCN, DARS2, NDUFAF6, PNPLA8, TWNK, and SDHA. The gene discussed is OBSCN; the disease is hepatocellular carcinoma.