Given the role of Aβ-regulated NLGN1 in driving synaptotoxicity in AD (51), we quantified AβOs in brain homogenates from both WT and Osbpl6−/− mice using a sandwich ELISA that allows the for the specific detection of oligomeric Aβ peptides, as previously (44, 45, 46, 47). Here, NLGN1 is linked to Alzheimer disease.