NOTCH1 and neoplasm: Genomic investigation of patient tumour using Whole Genome Sequencing (WGS) detected a series of heterozygous mutations with variant allele frequencies (VAF) between 0.1 and 0.27, of which 5 nonsynonymous mutations FAT3 (c.C12623T; VAF 0.27), NRG1 (c.C929T; VAF 0.21), SLFN5 (c.C1064T; VAF 0.21), CLRN1 (c.T275A; VAF 0.17), AKT1 (c.G49A; VAF 0.13), 1 frameshift deletion TNRC6C (c.1837delA; VAF 0.26) and 1 stop-gain mutation NOTCH1 (c.C7216T; VAF 0.10) were observed.