ALK and anaplastic large cell lymphoma: Notably, ALK-negative ALCL may be further stratified into distinct molecular subtypes based on genomic rearrangements of DUSP22 and TP63. These molecular alterations are mutually exclusive and make up a minority of ALK-negative ALCL, accounting for between 13 and 30% and 2–8% cases, respectively [3, 5–7].