Supporting our previous findings that LKB1 loss results in higher PER1 expression, we find that lung adenocarcinoma tumors with high expression of PER1 mRNA (Fig. 4A–B) or PER1 protein (Fig. 4C–D) are enriched for mutations in STK11. In both datasets, STK11 mutations are among the top three most significantly differentially altered genes between the Low and High PER1/PER1 groups. This evidence concerns the gene STK11 and lung adenocarcinoma.