PER1 and neoplasm: Generally, when data is analyzed without consideration of specific driver mutations or molecular subtype, PERs have been shown to possess tumor suppressor activity in a variety of cancers, with low PER1 expression associated with poorer prognosis in lung cancer patients taken as whole (Zhang et al. 2020; Cadenas et al. 2014; Deng et al. 2020; Chen et al. 2021; Gery et al. 2007).