KRAS and lung adenocarcinoma: To explore a different model, we made use of a cell line, JK43-M, derived from a metastatic lesion from our lab’s genetically-engineered mouse model of Kras/Stk11-mutant lung adenocarcinoma (Gilbert-Ross 2017;Richardson 2018) and again found that siRNA knockdown of Per1 decreased cell proliferation at 48 (p = 0.0001) and 72 (p = 0.0051) hours (Fig. 2D).