NOX4 and cancer: DUOX-generated H2O2 has also been connected to wound healing and long-range signaling in keratinocytes, zebrafish and Drosophila. In certain cell types including cancer cells H2O2 producing NADPH oxidases such as DUOX1/2 or NOX4 provide redox signaling for cytoskeletal dynamics, enhanced migration and metastasis12,13,48,49, while in other cell types NOX4 was dispensable and NOX1 promoted directed migration upon wounding50,51.