DUOX-generated H2O2 has also been connected to wound healing and long-range signaling in keratinocytes, zebrafish and Drosophila. In certain cell types including cancer cells H2O2 producing NADPH oxidases such as DUOX1/2 or NOX4 provide redox signaling for cytoskeletal dynamics, enhanced migration and metastasis12,13,48,49, while in other cell types NOX4 was dispensable and NOX1 promoted directed migration upon wounding50,51. The gene discussed is DUOX1; the disease is cancer.