REN and aortic stenosis: Importantly, this approach also uncovered targets with evidence in model systems, but not widely reported in human aortic stenosis, including pathways of extracellular matrix remodeling and oxidative stress (LTBP230,31, COL4A132, MATN233), cardiac development and hypertrophy responses (CRIM134,35), and renin-angiotensin metabolism (ACE236).