ENPP2 and hydrops fetalis: This proteo-transcriptional overlap identified a panoply of targets central to remodeling mechanisms (with several genes not widely described in human HF), including fibrosis (WNT9A81, ITGA645, AGRN46, CRIM147, SEMA4C48, LAYN42) and inflammation (ENPP2/ATX49, TNF family members).