In EBV infection, the latent membrane protein LMP1 activates NF-κB through a TRAF2/5-dependent mechanism, suppresses SH2D1A (SAP) expression, and promotes secretion of Th1-type cytokines such as TNF-α and IFN-γ35. The gene discussed is PDLIM7; the disease is Epstein-Barr virus infection.