CAV1 and hepatocellular carcinoma: This association between CAV1 overexpression in HBV+ HCC cell lines and inherent TKI resistance was observed exclusively in moderately-to-poorly differentiated HCC, as CAV1 expression in the well-differentiated HBV+ cell lines Hep3B [30] and PLC-PRF-5 [30] was negligible (Suppl.