Previous studies demonstrated that CAV1 regulates E-cadherin expression by inhibiting β-catenin-TCF/LEF1-dependent transcription of Snail [40] and exploits E-cadherin to inhibit colorectal cancer cell growth by sequestering β-catenin at the plasma membrane, which prevents transcription of survival genes such as survivin [41]. The gene discussed is HNF4A; the disease is colorectal cancer.