These findings were corroborated and independently validated by generating two additional sorafenib-resistant HCC cell lines from Hep3B cells: Hep3B/SR1 and Hep3B/SR2, both of which showed an increased expression of CAV1, F-actin, and RAC1 as compared to parental cells (Suppl. The gene discussed is CAV1; the disease is hepatocellular carcinoma.