Additionally, TKI-resistant cells displayed significant upregulation of cancer stemness markers (CD44, Myc and KLF4) with Huh-7/LR cells enriched for EpCAM, Sox2, Nanog and CD133, while Huh-7/SR1 cells expressed higher CD24 but lower Nanog (Suppl. The gene discussed is PROM1; the disease is cancer.