Using cell specific gene signatures from the scRNA-seq data, we detected CAV1 expression within the reactive stromal constituents, particularly, several immune cell types including cytotoxic CD8 + T cells, natural killer cells (NK), plasmacytoid dendritic cells (pDC) and tumour-associated macrophages (TAM), and other cell types such as PLPP3+ endothelial cells (EC), and lipid metabolising APOA2+ and pro-tumorigenic SDC2+ (syndecan 2) cancer-associated fibroblasts (CAF) (Fig. 7F). This evidence concerns the gene SDC2 and neoplasm.