To test the hypothesis that CAV1 drives resistance to both sorafenib and lenvatinib in HCC, we used a lentivirus transduction system to stably overexpress CAV1 in TKI-sensitive parental Huh-7 cells (Huh-7-CAV1-OE, Fig. 2E). The gene discussed is CAV1; the disease is hepatocellular carcinoma.