The immunosuppressive tumor microenvironment facilitates immune evasion by suppressing cytotoxic T-cell activity and promotes tumor progression through impaired immune surveillance.25 In our cohort, patients exhibiting disease progression demonstrated markedly diminished infiltration of immune cell infiltration levers, such as CD8 + T, CD4 + T, and M1 subtype of macrophages, indicating the immunosuppressive tumor microenvironment precluded the effectiveness of R-ICE-X treatment. Here, CD8A is linked to neoplasm.