In contrast, while basophil-derived IL-4 has been reported to play a critical role in allergic lung injury and AD [22, 34], the Il4 expression was comparable between WT and Il1rl1–/– basophils, consistent with in vitro data showing that IL-33 alone did not strongly induce Il4 expression (Fig. 1F). The gene discussed is IL33; the disease is Alzheimer disease.