The results of univariate analysis showed that CYP2C19 IM + PM phenotypes (IM + PM phenotypes vs. EM phenotype, odds ratio (OR): 1.300, 95% confidence interval (CI): 1.134–1.491, p < 0.001), BMI ≥ 24.0 kg/m2 (BMI ≥ 24.0 kg/m2 vs. BMI 18.5–23.9 kg/m2, OR: 1.319, 95% CI: 1.148–1.515, p < 0.001), history of smoking (yes vs. no, OR: 1.182 95% CI: 1.001–1.396, p = 0.049), and history of alcoholism (yes vs. no, OR: 1.817 95% CI: 1.227–2.584, p = 0.001) were significantly associated with CAD. Here, CYP2C19 is linked to coronary artery disorder.