Multivariate logistic regression analysis showed that CYP2C19 IM + PM phenotypes (IM + PM phenotypes vs. EM phenotype, OR: 1.314, 95% CI: 1.145–1.508, p < 0.001), BMI ≥ 24.0 kg/m2 (BMI ≥ 24.0 kg/m2 vs. BMI 18.5–23.9 kg/m2, OR: 1.364, 95% CI: 1.184–1.571, p < 0.001), and history of alcoholism (yes vs. no, OR: 1.761 95% CI: 1.211–2.559, p = 0.003) were independent risk factors for CAD in hypertensive patients (Table 5). This evidence concerns the gene CYP2C19 and alcohol drinking.