In our analysis of the correlation between IGLoS and the expression of 74 key immune modulators (Figure 2F), we found a consistent and highly positive correlation between the IGLoS signature and the PD1 (PDCD1) /PDL1 (CD274) axis, which has been widely proven to play a vital role in the maintenance of the anti‐tumor immune.[31] Therefore, we designed two siRNA sequences for each of the six genes in the IGLoS signature, to further screen targets that could regulate the PDL1 expression of glioma. Here, CD274 is linked to neoplasm.