PTGES and glioblastoma: proven that glioblastoma‐associated microglia/TAM secrete high levels of the proinflammatory cytokine IL11, which in turn, triggers the STAT3‐MYC signaling axis in glioblastoma cells to induce stem cell states that confer temozolomide resistance.[44] Microsomal prostaglandin E2 synthase‐1 (mPGES‐1), also known as PTGES, is the rate‐limiting enzyme responsible for the synthesis of prostaglandin E2 (PGE2) downstream of COX‐2.[45] Lalier et al.