The coexistence of potential crucial roles for regulators in both tumor cells and T cells has been validated by recent research for TNFAIP3, which has been identified as a key player in enhancing cancer cell susceptibility to immune attack and promoting T cell activation.[35] Hence, we are justified in postulating that TRAF3IP3 similarly manifests a dual functionality within these cellular contexts. This evidence concerns the gene TRAF3IP3 and cancer.