CD274 and central nervous system cancer: In our analysis of the correlation between IGLoS and the expression of 74 key immune modulators (Figure 2F), we found a consistent and highly positive correlation between the IGLoS signature and the PD1 (PDCD1) /PDL1 (CD274) axis, which has been widely proven to play a vital role in the maintenance of the anti‐tumor immune.[31] Therefore, we designed two siRNA sequences for each of the six genes in the IGLoS signature, to further screen targets that could regulate the PDL1 expression of glioma.