CDK4 and central nervous system cancer: The CDK4‐cyclin D1 axis is critical for glioma genesis, tumor de t velopment, and the growth of stromal‐derived cells in the surrounding microenvironment, which sustains the spread of glioma cells.[59] Despite its good tolerance, palbociclib monotherapy did not show favorable efficacy against recurrent anaplastic oligodendroglioma and recurrent glioblastoma.[60, 61] Although none of the three drugs have entered further clinical trials, all have moved from preclinical to clinical trials, suggesting that our screening pipeline is reasonable.