UBAP2 has been reported to facilitate the ubiquitination of PAICS in melanoma and SLC27A5 in hepatocellular carcinoma.[38, 39] We hypothesize that SNORA58 may function as a guide RNA to recruit UBAP2 to CTCF, thereby enhancing CTCF ubiquitination. This evidence concerns the gene UBAP2 and hepatocellular carcinoma.