For example, SNORA42 has been shown to promote ESCC development by activating the DHX9/p65 axis,[18] and SNORD12B activates the AKT‐mTOR‐4EBP1 signaling pathway to enhance malignant phenotypes in ESCC.[19] Radiotherapy represents one of the primary treatment modalities for advanced ESCC. The gene discussed is EIF4EBP1; the disease is esophageal squamous cell carcinoma.