Second, Although we observed that the numbers of CD3 + T cells, CD19 + B cells, and F4/80 + macrophages in 4NQO-induced esophageal cancer tissues did not differ significantly between WT and Ttpal-KO mice, whether simvastatin affects tumor immunity in Ttpal-KO mice remains to be further investigated. This evidence concerns the gene TTPAL and esophageal cancer.