NSUN2 and esophageal squamous cell carcinoma: Collectively, these results delineate a novel epigenetic-metabolic axis wherein TTPAL amplification coordinates RNA methylation (via NSUN2 stabilization) and cholesterol overproduction to fuel ESCC progression, establishing a mechanistic link between genomic alterations, epigenetic remodeling, and metabolic vulnerability in esophageal carcinogenesis.