AD, Alzheimer’s Disease; FC, fold change; FTLD-TAU, frontotemporal lobar degeneration with TAU pathology; FTLD-TDP, frontotemporal lobar degeneration with TDP-43 pathology; GO, gene ontology; n.s., not significant; SD, semantic dementia; SynGO, synaptic gene ontology; TC, temporal cortex. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.