Post-mortem pathological examination shows specific TDP-43 positive protein aggregates in the brain, a neuropathological entity classified as frontotemporal lobar degeneration (FTLD) TDP type C. This type is characterized by the presence of long dystrophic neurites in the temporal cortex compared to round, neuronal inclusions in the dentate gyrus of the hippocampus [13, 39]. This evidence concerns the gene TARDBP and frontotemporal dementia.