Clinical variables associated with the 6-month adverse outcome were admission GCS (OR 0.77 95% CI 0.67–0.87, p < 0.001), age (OR 1.10 95% CI 1.03–1.1, p = 0.001), Rotterdam score (OR 2.8 95% CI 1.7–5.0, p < 0.001), hospital infections (OR 4.7 95% CI 1.9–12.1, p < 0.001) and day-0 IL-6 (OR 1.1 95% CI 1.08–1.13, p < 0.001). This evidence concerns the gene IL6 and infection.