Our data suggest that patients positive for anti-GAD65 should be screened for anti-CN1A-associated diseases, and that a more comprehensive evaluation of anti-CN1A in anti-GAD65-associated autoimmune diseases (e.g. T1DM, vitiligo, Hashimoto’s thyroiditis) may clarify the links between systemic autoimmunity and epilepsy. Here, NT5C1A is linked to autoimmune disease.