GAD2 and focal epilepsy: Subsequent mass spectrometric analysis revealed enriched protein concentrations of CN1A with a high abundance ratio and a significant Mascot score (molecular weight 40-kDa, Fig. 1C) in two anti-GAD65-positive index patients verified in two independent experiments, which were not present in any of the controls (n = 3 control patients with focal epilepsy without any signs of autoimmune encephalitis, n = 3 healthy controls).